The role of COX inhibitors in various physiological systems
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چکیده
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) act by inhibiting the cyclo-oxegenase (COX) enzyme, which is responsible for prostaglandin H2 (PGH2) synthesis. Inhibition of PG results in pain relief and reduction of inflammation.1,2,3,4 However, the majority of NSAIDs inhibit PGs found all over the body and not only at the location of the inflammation, causing side effects like gastrointestinal (GI) and renal toxicity, as well as impairment of platelet function.1
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